Abstract 220: Higher Odds Of Medication Non-compliance In Hospitalized Young Adults With Cannabis Use Disorder: A Nationwide Population-Based Study

Background: Medication non-compliance (MNC) is both a health and an economic burden. Considering a paucity of large-scale contemporary data, we aim to compare the rate of MNC in young adults hospitalized with vs without dependent cannabis use (cannabis use disorder) and study the risk factors of MNC.

Methods: Young (18-44 years) patients with MNC were extracted from the National Inpatient Sample 2018 (ICD10 codes), divided into having and not having cannabis use disorder (CUD+ and CUD-). Rates of MNC were compared between 2 cohorts, CUD+ vs CUD-. Multivariate analysis was performed for predictors of MNC with CUD+.

Results: Young hospitalized adults with CUD+ had an overall higher rate of MNC (7.2 vs 2.2%) vs CUD- cohort (p<0.001) [Table 1]. On subgroup analyses, significantly higher rates of MNC in CUD+ were seen in males (8 vs 4.2%), females (6 vs 1.4%), white (6.2 vs 1.4%), black (9.6 vs 3.8%), Hispanic (6.6 vs 1.7%), Asian/Pacific Islanders (6.7 vs 1%), Medicare enrollees (11.7 vs 5.8%), Medicaid enrollees (7.7 vs 2.8%), private insurees (4.9 vs 0.9%), in patients with concomitant depression (6.4 vs 3.7%), psychosis (8.3 vs 5.6%), alcohol abuse (7.3 vs 4.8%), tobacco use disorder (8.0 vs 4.5%) and overall drug abuse (7.6 vs 6.9%). When adjusted for confounders, young adults with CUD+ had higher odds of hospitalization with MNC vs. patients without CUD (aOR 1.19, 95CI 1.14-1.24, p<0.001). Statistically significant predictors for MNC in young adults with CUD were males (vs females, aOR 1.41, 95CI 1.31-1.52), blacks (vs whites, aOR 1.42, 95CI 1.28-1.57), psychosis (aOR 1.25, 95CI 1.12-1.40), tobacco use (aOR 1.36, 95CI 1.24-1.50) and drug abuse (aOR 1.92, 95CI 1.61-2.29).

Conclusion: Medication non-compliance was significantly higher in all subgroups of young adults with CUD, with concomitant depression, psychosis, tobacco and alcohol use compared to non-cannabis users. Males, blacks, patients with psychosis, tobacco and drug users were likely to have MNC.